Amoeba story is already done. In Legend of Zelda, we have a backstory for Morpha, the giant sized single nucleus Amoeba with flexible shape and giant tentacles. Morpha 'was' one of the ex-lovers of Princess Ruto, savagely killed by Ganondorf and reincarnated to single celled gigantic form, enslaved to protect The Water Temple. Morpha's a Zoran too.
So if Rajamouli makes a sequel on those lines, all us Nintendo/Zelda fans will line up in Morphan costume in protest.